Organization of the Manuscript
Manuscripts must be written in English. Multiple-part papers are
discouraged. Although it is recognized that this arrangement is
sometimes necessary, authors will often be asked to collapse multiple
papers into a single manuscript.
Manuscripts must include the sections listed below in the order they are
presented. All word limits include citations. The entire text should be
double-spaced. Submitting an incomplete manuscript or a manuscript that
does not adhere to the word limits will cause a delay in review.
Communications are subject to the same word restrictions, with the
additional requirement that the abstract, introduction, materials and
methods, results, discussion references and figure legends cannot exceed
first page of the manuscript should be a title page with the following:
Journal Section (Cellular & Molecular, Neurobiology
of Disease, Behavioral/Systems/Cognitive, or
Authors and author addresses
Corresponding author with complete address, including
an email address
should be used to note intellectual, technical or other assistance that
does not warrant authorship as well as to identify all funding sources.
Individuals should be informed before the publication of any such
acknowledgements and given the opportunity to decline the recognition.
Promotional statements are not permitted.
(250 words maximum, including citations)
abstract should be clearly written and readily comprehensible. It should
provide a concise summary of the objectives, methodology (including the
species studied), key results, and major conclusions of the study. It
should be written in complete sentences, without subheadings.
Introduction (450 words maximum, including citations)
Introduction should briefly indicate the objectives of the study and
provide enough background information to clarify why the study was
undertaken and what hypotheses were tested.
Materials and Methods
Materials and methods section should be brief but sufficient to enable
other investigators to repeat the research. Reference should be made to
published procedures wherever possible; this applies to the original
description and pertinent published modifications. The sex of subjects
should be stated. All companies from which materials were obtained
should be listed. If materials were obtained from an individual, an
affiliation for that individual should be listed.
the Materials and Methods may be placed in Supplemental Materials.
result section should present clearly the experimental findings. Only
results essential to establish the main points of the work should be
included. Numerical data should be analyzed using appropriate
Discussion (1000 words maximum, including citations)
Discussion section should be concise and must include a brief statement
of the principal findings, a discussion of the validity of the
observations, a discussion of the findings in light of other published
work dealing with the same or closely related subjects, and a statement
of the possible significance of the work.
DP, Martin A, Julie E, Alback GB (1984). Improved patch-clamp techniques
for high-resolution current recordings from cells and cell free membrane
patches. Pflugers Arch 391:85-100.
Brivial AL, Hayles AN (1952). The components of membrane conductance in
the giant axon of Loligo. J Physiol (Lond) 116:473-496.
tables must be numbered independently of figures, multimedia and 3D
models and cited at the relevant point in the manuscript text, e.g.
"Table 1", "Table 2", etc.
should appear above the table.
for each table must be included in the manuscript document after the
reference list. Legends should include sufficient detail to be
intelligible without reference to the text. Legends must define all
symbols and include essential information, such as scale bar dimensions.
must be numbered independently of tables, multimedia, and 3D models and
cited at the relevant point in the manuscript text, e.g. "Figure 1",
"Figure 2", etc.
should be part of the legend and not lettered onto the figure.
must be included in the manuscript document after the reference list.
Legends should include sufficient detail to be intelligible without
reference to the text. Legends must define all symbols and include
essential information, such as scale bar dimensions. Rather than stating
"See text," legends should be more specific; for example, "See Results".
must be submitted at the size they are to appear in PRE.
They should be the smallest size that will convey the essential
scientific information, and sized to 1column (8.5 cm), 1.5 columns (11.6
cm) or 2 columns (17.6 cm).
Initial Submission – figures may be included in a
single PDF file that contains the manuscript and all tables and
Revised Submission - Figures must be submitted only
as separate files in TIFF or EPS format.
figures should be in RGB format and supplied at a minimum of 300 dpi.
Brief Communications are short research articles intended
to present exciting findings that will have a major impact in the
journal. Brief Communications are limited to 3,500 words, including the
abstract, introduction, materials and methods, results, discussion,
references and figure legends. It
is suitable for recording the results of complete small investigations
or giving details of new models or hypotheses, innovative methods,
techniques or apparatus.
occasionally be published consisting of nonempirical reports,
theoretical notes, or criticism on topics pertinent to the journal's
proofs of the manuscript will be sent to the corresponding author as a
PDF file. Page proofs are regarded to be the final version of the
manuscript. Authors will have free electronic access to the full text
(in both HTML and PDF) of the article which can freely download the PDF
file from which they can print unlimited copies of their articles.
Handling Fee: Authors
are required to pay a $400 handling fee for the publication of their
manuscript. Although Authors may still request (in advance) that the
editorial office waive some of the handling fee under special
circumstances (not more than 10%).