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Prime Research on Biotechnology

ISSN: 2315-5299

Volume 2, Issue 4, pp. 53-56

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Hypoglycemic activity of aqueous extract of the bark of bridelia ferruginea in normal and alloxan-induced diabetic rats


Adewale OB and Oloyede OI


1Department of Chemical Sciences (Biochemistry unit), College of Sciences, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria.

2Department of Biochemistry, Faculty of Science, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria.


Accepted 18th October, 2012



The hypoglycemic activity of the aqueous extract from stem bark of Bridelia ferruginea was investigated in both normal and alloxan-induced diabetic rats. Rats were made diabetic by the administration of alloxan (150mg/kg body weight) intraperitoneally. Fasting blood glucose level greater than 300mg/dl indicates diabetes mellitus. Diabetic rats were treated with 100mg/kg of the extract. The extract significantly reduced the blood glucose level of normal rats at the tested dose 24 hours after oral administration (p< 0.05) from 45.00 + 2.65 to 32.67 + 1.53 mg/dl and also reduced the blood glucose level of alloxan-induced diabetic rats from 547.50 + 74.25 to 450.00 + 14.14 mg/dl. Glucose tolerance in normal rats was enhanced which shows that there is marked improvement in glucose utilization after administration of this extract. The result obtained in this study revealed the mechanism of hypoglycemic activity of Bridelia ferruginea to repair the β-cells that has been destroyed by the alloxan monohydrate within few hours. This implies that the aqueous extract from this plant stimulates the reduction of the blood glucose by acting directly as insulin or enhancing the release of insulin.


Keywords: Hypoglycemic activity, Bridelia ferruginea, alloxan, glucose tolerance, insulin.



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Adewale OB

Oloyede OI



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