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Prime Journal of Microbiology Research

 Prime Journal of Microbiology Research | ISSN: 2251-127X

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Prime Journal of Microbiology Research

ISSN: 2251-127X. Volume 2, Issue 5, pp. 137-140

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Full Length Research

 

Application of oxidants to the spectrophotometric microdetermination of meclizine Hcl in pure and pharmaceutical formulations

Abdel-Azem Mohammed
, El-Sharkawy Talaat, Yonis Mohamed, and Sayed Ahmed Shama

Faculty of Science, Chemistry Department, Benha University, Benha, Egypt.

Accepted 17th October, 2012

 
Abstract

Two simple, rapid, sensitive and accurate methods (A and B) have been established and developed for the microdetermination of meclizine hydrochloride in pure form and in pharmaceutical formulations. These two methods are based on the oxidation of the cited drug with Fe (III) in acidic medium. The formed Fe (II) reacts with 1,10-phenanthroline (method A) and the ferroin complex is measured spectrophotometrically at λmax 510 nm against reagent blank. Method B is based on the reaction of the formed Fe (II) with 2,2'-bipyridy to form a stable colored complex at λmax 521 nm. Optimization of the experimental conditions was described. Beer’s law was obeyed in the concentration range of 0.4-11 μg ml-1 by using method A and 0.5-21 μg ml-1 by using method B. The apparent molar absorptivity for method A is 4.76 x 104 and for method B is 3.66 x 104 L mol-1 cm-1, respectively. The suggested procedures can be used for the determination of meclizine hydrochloride in both pure and dosage forms without interference from common excipients.

Keywords:
Spectrophotometric, meclizine hydrochloride, pharmaceutical formulation, 1,10-phenanthroline and 2,2'-bipyridyl.

 

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Abdel-Azem M

 El-Sharkawy T

 Yonis M

 Sayed AS

 

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